TOOLKIT

Thank you for registering for enduring courses from the Betsy Poon Continuing Education Series: 2021 Hot Topics in Pediatric Oncology! You can watch all the videos here, or click the titles below.

Practical Considerations

• Children’s Oncology Group (COG) Pharmacist Webpage (membership required)
• COG Solid Tumor Chemotherapy Guidelines (membership required)
• vinCRIStine Mini-Bags: ISMP Press Release
• Pegaspargase & Calaspargase Information
  • Managing Asparaginase Toxicities – Burke PW, et al. Managing Toxicities with Asparaginase-Based Therapies in Adult ALL: Summary of an ESMO Open-Cancer Horizons Roundtable Discussion. ESMO Open 2020;5
  • How I Treat the Toxicities of Pegasparaginase in Adults with Acute Lymphoblastic Leukemia
  • Management Summary of Pegaspargase Toxicity in Adults
  • Calaspargase Pharmacokinetics – Angiolillo AL, et al. Pharmacokinetic and Pharmacodynamic Properties of Calaspargase Pegol Escherichia coli L-Asparaginase in the Treatment of Patients with Acute Lymphoblastic Leukemia: Results from the Children’s Oncology Group Study AALL07P4. J Clin Oncol 2014;32:3874-3882.
  • Pegaspargase vs. Calaspargase – Vrooman LM, et al. Efficacy and Toxicity of Pegaspargase and Calaspargase Pegol in Childhood Acute Lymphoblastic Leukemia: Results of DFCI 11-001. 2021;39:3496-3505.

Best Abstracts

• Chemotherapy-Induced Nausea and Vomiting (CINV): Guidelines and References
  • Guideline for Treatment and Prevention of CINV in Children
  • Guideline for Prevention of Acute CINV in Pediatric Cancer Patients
  • Safety of Clinical Practice Guideline-Recommended Antiemetics in Pediatrics
  • Palonosetron vs. Ondansetron – Kovács G, et al. Palonosetron versus ondansetron for prevention of chemotherapy-induced nausea and vomiting in paediatric patients with cancer receiving moderately or highly emetogenic chemotherapy: a randomised, phase 3, double-blind, double-dummy, non-inferiority study. The Lancet Oncology 2016;17:332-344.
• Erwinia Asparaginase Rapid Desensitization
  • Drug Desensitization: What it Is & How It Works
  • Consensus Statement on Rapid Desensitization
  • Rapid Desensitization to Chemotherapy – Castells M. Rapid Desensitization for Hypersensitivity Reactions to Chemotherapy Agents. Curr Opin Allergy Clin Immunol 2006;6:271-7.
• Peg-asparaginase Reactions
  • Common Terminology Criteria for Adverse Events version 5.0
  • Application of Asparaginase Activity Levels – Bleyer A, et al. Clinical Application of Asparaginase Activity Levels Following Treatment with Pegaspargase. Pediatr Blood Cancer 2015;62:1102-5.

Neuroblastoma Treatment Timeline

• Neuroblastoma References & Resources

Emerging Therapies in Pediatric Brain Tumors

• Pediatric Brain Tumor Consortium (PBTC)
• Pacific Pediatric Neuro-Oncology Consortium (PNOC)
• Biology of Pediatric Brain Tumors – Gajjar A, et al. Molecular Insights into Pediatric Brain Tumors Have the Potential to Transform Therapy. Clin Cancer Res 2014;20:5630-40.
• Brain Tumors E-Book: An Encyclopedic Approach

New/Emerging Therapies in Leukemia & Lymphoma

• Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Clinical Trials
• QTc Prolonging Medications Database (Credible Meds)
• Decitabine + Vorinostat + Chemo in Relapsed ALL – Burke MJ, et al. Decitabine and Vorinostat with Chemotherapy in Relapsed Pediatric Acute Lymphoblastic Leukemia: A TACL Pilot Study. Clin Cancer Res 2020;26:2297-307.

New/Emerging Therapies in Histiocytoses

• Histiocyte Society
• North American Consortium for Histiocytosis (NACHO)
• Max the Angry Macrophage – A Story About HLH
• Select Hemophagocytic Lymphohistiocytosis (HLH) Clinical Trial Summaries